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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PLK1
All Species:
51.82
Human Site:
Y260
Identified Species:
71.25
UniProt:
P53350
Number Species:
16
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P53350
NP_005021.2
603
68255
Y260
T
S
C
L
K
E
T
Y
L
R
I
K
K
N
E
Chimpanzee
Pan troglodytes
XP_001163623
603
68223
Y260
T
S
C
L
K
E
T
Y
L
R
I
K
K
N
E
Rhesus Macaque
Macaca mulatta
XP_001092070
603
68240
Y260
T
S
C
L
K
E
T
Y
L
R
I
K
K
N
E
Dog
Lupus familis
XP_547091
832
93293
Y488
T
S
C
L
K
E
T
Y
L
R
I
K
K
N
D
Cat
Felis silvestris
Mouse
Mus musculus
Q07832
603
68282
Y260
T
S
C
L
K
E
T
Y
L
R
I
K
K
N
E
Rat
Rattus norvegicus
Q62673
603
68295
Y260
T
S
C
L
K
E
T
Y
L
R
I
K
K
N
E
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001505317
482
55166
A157
K
H
I
N
P
V
A
A
S
L
I
Q
K
M
L
Chicken
Gallus gallus
NP_001025810
595
66904
Y250
T
S
C
L
K
E
T
Y
I
R
I
K
K
N
E
Frog
Xenopus laevis
P70032
598
68193
Y251
T
S
C
L
K
E
T
Y
M
R
I
K
K
N
E
Zebra Danio
Brachydanio rerio
NP_001003890
595
67743
Y246
T
S
C
L
K
E
T
Y
I
R
I
K
K
N
E
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P52304
576
66955
Y232
T
K
T
L
K
D
T
Y
S
K
I
K
K
C
E
Honey Bee
Apis mellifera
XP_396707
575
66141
Y230
T
S
S
L
K
E
T
Y
A
R
I
K
Q
V
Q
Nematode Worm
Caenorhab. elegans
P34331
649
73615
Y245
S
K
S
L
E
E
T
Y
S
R
I
R
H
N
N
Sea Urchin
Strong. purpuratus
XP_784826
587
66895
Y234
T
Q
S
L
K
D
T
Y
Q
R
I
K
R
N
E
Poplar Tree
Populus trichocarpa
Maize
Zea mays
P0C8M8
626
70215
T243
E
T
S
D
V
K
Q
T
Y
K
R
I
K
A
C
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9STV4
445
50410
V120
F
H
Q
L
I
D
G
V
D
Y
C
H
S
K
G
Baker's Yeast
Sacchar. cerevisiae
P32562
705
81013
T288
F
Q
A
R
D
V
N
T
I
Y
E
R
I
K
C
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.8
99.8
69.5
N.A.
95
94.1
N.A.
69.3
80
79.7
74.3
N.A.
50.7
51.4
49.9
59.3
Protein Similarity:
100
99.8
99.8
71
N.A.
97.6
96.8
N.A.
74.7
89.8
90.5
87.5
N.A.
69.4
69.9
66.2
76.4
P-Site Identity:
100
100
100
93.3
N.A.
100
100
N.A.
13.3
93.3
93.3
93.3
N.A.
60
66.6
46.6
66.6
P-Site Similarity:
100
100
100
100
N.A.
100
100
N.A.
20
100
100
100
N.A.
73.3
80
66.6
80
Percent
Protein Identity:
N.A.
31.7
N.A.
26
33.9
N.A.
Protein Similarity:
N.A.
50.1
N.A.
40.4
51.6
N.A.
P-Site Identity:
N.A.
6.6
N.A.
6.6
0
N.A.
P-Site Similarity:
N.A.
26.6
N.A.
13.3
13.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
6
0
0
0
6
6
6
0
0
0
0
6
0
% A
% Cys:
0
0
53
0
0
0
0
0
0
0
6
0
0
6
12
% C
% Asp:
0
0
0
6
6
18
0
0
6
0
0
0
0
0
6
% D
% Glu:
6
0
0
0
6
65
0
0
0
0
6
0
0
0
59
% E
% Phe:
12
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
6
0
0
0
0
0
0
0
6
% G
% His:
0
12
0
0
0
0
0
0
0
0
0
6
6
0
0
% H
% Ile:
0
0
6
0
6
0
0
0
18
0
83
6
6
0
0
% I
% Lys:
6
12
0
0
71
6
0
0
0
12
0
71
71
12
0
% K
% Leu:
0
0
0
83
0
0
0
0
36
6
0
0
0
0
6
% L
% Met:
0
0
0
0
0
0
0
0
6
0
0
0
0
6
0
% M
% Asn:
0
0
0
6
0
0
6
0
0
0
0
0
0
65
6
% N
% Pro:
0
0
0
0
6
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
12
6
0
0
0
6
0
6
0
0
6
6
0
6
% Q
% Arg:
0
0
0
6
0
0
0
0
0
71
6
12
6
0
0
% R
% Ser:
6
59
24
0
0
0
0
0
18
0
0
0
6
0
0
% S
% Thr:
71
6
6
0
0
0
77
12
0
0
0
0
0
0
0
% T
% Val:
0
0
0
0
6
12
0
6
0
0
0
0
0
6
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
77
6
12
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _